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American Medical Association Establishes Category III CPT Code for Procedure Associated with the Use of MuReva Phototherapy’s LED-based Photobiomodulation Therapy Device

Obtaining this CPT code is an initial step to achieving reimbursement for the use of MuReva Phototherapy’s Photobiomodulation Therapy Device when it becomes commercially available Brecksville, Ohio (December 16, 2025) – MuReva Phototherapy, an emerging leader in the treatment of radiation- and chemotherapy-induced oral mucositis in cancer patients, today announced that…
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“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS

“Through many studies and systematic reviews, PBM has demonstrated efficacy in preventing the incidence and severity of OM in patients receiving radiation therapy for head and neck cancers. For a company like MuReva to [produce] a really rigorously engineered device that’s really simple to use and train a center on: that’s what’s needed for the field.”

Nathaniel Simon Treister, DMD
Chief, Division of Oral Medicine and Dentistry, Associate Professor of Oral Medicine, Infection, and Immunity

“We saw a patient that was enrolled in the PBM trial who was very concerned of developing painful mouth sores from OM and did not because of the Mureva device. The patient was crying because of happiness, because he didn’t have any mouth sores or any pain. To me, that’s success.“

Alessandro Villa, DDS, PhD, MPH
Chief of Oral Medicine, Oral Oncology, and Dentistry, President ISOO

“The benefit to using Mureva PBM is significant in the reduction of oral mucositis for patients undergoing head and neck cancer therapy. They do better, they have less pain, less mucositis, and overall feel better.”

Jennifer Frustino, DDS, PhD, MS
Director of Oncology Research, Staff Clinician in the Division of Oral Oncology and Maxillofacial Prosthetics
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